Natural selection and the evolution of the invasive trophoblast in hominoid primates [electronic resource] / by Paul M. Litman

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Material Type
Manuscript
Author
Litman, Paul M.

More Details

Imprint
2006.
Descript
183 p. : ill. (some col.)
Note
Title from document title page.
ECM
Evolution
Ka/Ks
MMP
Placenta
Reproduction
TIMP
Summary
Humans and apes (hominoids) differ from Old World monkeys (OWMs) in the depth of placental trophoblast invasion. OWMs have a superficial placentation, with little invasion of the trophoblast into the uterine endometrium, while hominoids, and humans in particular, have a more invasive trophoblast, allowing for increased blood flow and nutrients to the developing fetus. This dramatic, morphological change, occurring on the hominoid stem branch and human lineage, may be explained by positive selection of genes involved in trophoblast implantation, resulting in the origin of the invasive trophoblast. Comparative sequencing of cell adhesion molecules, proteinases, and proteinase inhibitors involved in trophoblast implantation, in representative OWM and hominoid species, revealed uniform, purifying selection, with little differences between the hominoid stem branch, the human lineage, and the rest of the tree, suggesting that positive selection on these genes alone may not account for the phenotypic differences between humans and our primate relatives.
Note
System requirements: PC, World Wide Web browser and PDF reader.
Mode of access: World Wide Web.
Abstract included in electronic submission form.
Thesis (M.S.)--Duquesne University, 2006.
Bibliog.
Includes bibliographical references (p. 93-96) and index.
Note
Faculty advisor: Michael I. Jensen-Seaman.
Subject
Trophoblast.
Hominids -- Evolution.
Genetic regulation.
Placenta -- Blood-vessels.
MARC
OCoLC
20090626085317.0
m d
cr mn|nnnancun
090626s2006 xx a sb 001 0 eng dntmIa
DUQ DUQ
DUQQ
Computer data (1 file)
http://digital.library.duq.edu/u/?/etd,6873 Access via Duquesne University Electronic Theses and Dissertations website - USE RESTRICTED TO DUQUESNE UNIVERSITY CAMPUS ONLY.
C0 DUQ
http://digital.library.duq.edu/u/?/etd,6873 Access via Duquesne University Electronic Theses and Dissertations website - USE RESTRICTED TO DUQUESNE UNIVERSITY CAMPUS ONLY.